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KMID : 1189420050180030055
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2005 Volume.18 No. 3 p.55 ~ p.65
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The Effects of Gudambope-tang on the Rat Model with Allergic Rhinitis
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Jung Se-Yeon
Kim Yoon-Bum
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Abstract
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Objectives: Allergic rhinitis is an inflammation or irritation of the mucous membranes that line the nose. Common symptoms include sneezing; a stuffy or runny nose; itchy eyes, nose and throat; and watery eyes. We aimed to determine therapeutic effects of Gudambope-tang by observing changes in blood cells and the nasal mucosal tissue.
Methods: Fifteen Spraque-Dawley rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitoneal and intranasal sensitization with 0.1% ovalbumin solution. Then Gudambope-tang was orally administered only to the sample group for 28days, while the rats in the control group was given normal saline. We observed changes in the number of RBC and WBC; changes of neutrophil, Iymphocyte and monocyte proportions; total IgE level and AST & ALT changes; also, changes in the nasal mucosal tissue. We used ANOVA test statistically(p<0.05).
Results: 1. Gudambope-tang showed an inhibitory effect on the process of allergic rhinitis. 2. Gudambope-tang inhibited the inflammatory reaction on the nasal mucosal tissue. 3. Gudambope-tang had no hepatoxicity.
Conclusions: According to the above results. it is considered that Gudambope-tang has an inhibitory effect on the process of allergic rhinitis and it can be used in relieving symptoms of allergic rhinitis.
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KEYWORD
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AllergicRhinitis, Gudambope-tang, Ovalbumin, TotalIgE, NasalMucosa
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